SDHB and neoplasm: As the majority of wtGIST are SDH-deficient, these tumours exhibit upregulation of hexokinase receptors [31] and increased 18F-FDG uptake, and therefore, it is likely that this may mitigate any benefit of 18F-FDG PET/CT in determining therapeutic response to tyrosine kinase inhibitors in wtGIST, but 18F-FDG PET/CT remains a sensitive imaging modality for SDH deficient tumours [31] although it lacks the ability to differentiate between tumour types (e.g. PGL versus wtGIST).