AGT and Hypertension: In 2005, de Ciuceis et al. published about the link between innate immune cells and arterial hypertension in mice: They infused osteopetrotic mice (Op/Op)—a mouse strain deficient in macrophage colony-stimulating factor (m-CSF)—with AngII and found reduced systolic blood pressure values as well as a protection from vascular dysfunction in the absence of m-CSF [17].