Chen et al. published that AngII-infused mice deficient for C5a and C3a receptors did not develop arterial hypertension by a decreased renal macrophage and T cell infiltration [72]; moreover, Zhou et al. showed that C3a activates the RAAS system by induction of epithelial-to-mesenchymal transition in renal epithelial cells [73]. The gene discussed is C3; the disease is Hypertension.