Indeed, the heart‐enriched lncRNA cardiac‐hypertrophy‐associated epigenetic regulator (Chaer), can epigenetically interact with the Polycomb Repressor Complex 2 (PRC2) and inhibit histone H3 lysine 27 methylation at the promoter regions of genes involved in cardiac hypertrophy, thus inducing the expression of genes involved in cardiac hypertrophy, with studies performed in rat, murine, and human cells.112. Here, CHAER1 is linked to cardiac hypertrophy.