In turn, the upregulation of ROS levels by PKC-dependent activation of Nox enzymes may amplify PKC signaling (Giorgi et al., 2010; Gopalakrishna and Jaken, 2000), and has been suggested to be involved in various pathophysiological conditions, including human cardiovascular diseases (Cosentino-Gomes et al., 2012). Here, PRRT2 is linked to cardiovascular disorder.