Isotype analysis indicated that the rMVAs induced a well-balanced predominantly Th1 type response with IgG2a or IgG2c (depending on the mouse strain) > IgG2b > IgG1 > IgG3, which is the usual order following a viral infection and by IFNγ stimulation (45–47). This evidence concerns the gene IGHG3 and viral infectious disease.