IL6 and viral infectious disease: IL-6 is an important mediator of poly I:C- and virally-induced behavioural changes in the offspring of maternal immune activation models (Matsumoto & Seya, 2008b; Murray et al., 2015) so it is apparent that levels of IFN-I and IL-6 are intimately linked and models purporting to mimic viral infection must be cognisant of this deficiency as well as the variability inherent in LMW preparations.