By targeting β-catenin and CDH11 to regulate the typical Wnt-signaling pathway and inhibit the cancer stem cell (CSC) like phenotype and metastasis phenotype of TNBC cells, it represents a new method of TNBC treatment, which provides a basis for further exploring CDH11 as a candidate target of TNBC targeted treatment 36,37. The gene discussed is CDH11; the disease is cancer.