Consistent with the possibility that CDH11 may participate in bone metastasis in breast cancer and PCa in former researches, studies have indicated that CDH11 is involved in bone organ-specific metastasis of 786-O cell lines by increasing the migration of renal cell carcinoma (RCC) cells or the adhesion of RCC to osteoblasts in bone marrow 47. The gene discussed is CDH11; the disease is posterior cortical atrophy.