Consistent with the possibility that CDH11 may participate in bone metastasis in breast cancer and PCa in former researches, studies have indicated that CDH11 is involved in bone organ-specific metastasis of 786-O cell lines by increasing the migration of renal cell carcinoma (RCC) cells or the adhesion of RCC to osteoblasts in bone marrow 47. Here, CDH11 is linked to hereditary clear cell renal cell carcinoma.