44, 70 GDF-15 and GFRAL signaling pathways are thus suggested to be an important potential therapeutic target for both cancer cachexia and obesity.7, 16, 42, 46, 54, 71 Thus, both GDF15 and GFRAL signaling through the tyrosine kinase receptor RET18, 46 are under investigation in several clinical trials.43, 46 (Table 1). This evidence concerns the gene GFRAL and cancer.