Based on the contribution of ID1 to the dedifferentiation of somatic cells 12 and the concomitant effects of NF-κB on the proliferation of cells and induction of epithelial-mesenchymal transition (EMT), it is highly plausible that these pathways may function synergistically in HNSCC development and progression. Here, NFKB1 is linked to head and neck squamous cell carcinoma.