In the present study, we investigated the role of Nrf2/HO-1 signaling pathway in angiogenesis of gastric cancer and whether DS could decrease vascular endothelial growth factor (VEGF) expression to suppress angiogenesis by down-regulating Nrf2/HO-1 signaling pathway in gastric cancer under hypoxic microenvironment. This evidence concerns the gene NFE2L2 and gastric cancer.