A panel of module gene signatures, H2AFX, MCM2, MCM7, and POLD1, were highly related to NSCLC; and the high expression levels of MCM2, MCM7, H2AFX, and POLD1 were also correlated with poor prognosis, suggesting their potential role in tumorigenesis. This evidence concerns the gene MCM7 and non-small cell lung carcinoma.