TLR4 mRNA expression markedly increased in all patient groups including group 2 (non-DM + HD), group 3 (DM + HD), and group 4 (DM) groups recording percentage changes of3.13.4, 920.6, and 60.8%, respectively as compared to normal; the most potent deleterious effect was attained in DM + HD group. Here, TLR4 is linked to diabetes mellitus.