JUN and heart failure: Heart failure is one of the age-related disorder in mammals, where the IGF-Akt on sustained activation promotes hypertrophy and heart failure (Wang et al., 2015; D’Onofrio et al., 2017; Lee and Kim, 2018), whereas Sirt6 impedes IGF-Akt signaling via c-Jun by deacetylation of H3K9 (Sundaresan et al., 2012).