Mice placed on caloric restriction or Sirt6 activators overexpress Sirt6, improving cancer, and age-related disorders in animal models (Zhang et al., 2016a; Kuang et al., 2018; Iachettini et al., 2018; Rahnasto-Rilla et al., 2018), on the contrary, lower Sirt6 levels in mice showed shorter life expectancy, cancer occurrence, diabetes and other metabolic disorders increased. The gene discussed is SIRT6; the disease is diabetes mellitus.