This binding led to a significant and overall increase in deacetylation of H3K9ac and H3K56ac in HCC (human-hepatocellular-carcinoma cells) which prevented the proliferation and differentiation of HCC cells through cell cycle arrest thus proving that the activation of Sirt6 is crucial in the treatment of Hepatocellular Carcinoma (Huang et al., 2018). The gene discussed is SIRT6; the disease is hepatocellular carcinoma.