Mice placed on caloric restriction or Sirt6 activators overexpress Sirt6, improving cancer, and age-related disorders in animal models (Zhang et al., 2016a; Kuang et al., 2018; Iachettini et al., 2018; Rahnasto-Rilla et al., 2018), on the contrary, lower Sirt6 levels in mice showed shorter life expectancy, cancer occurrence, diabetes and other metabolic disorders increased. This evidence concerns the gene SIRT6 and Other metabolic disease.