INS and type 2 diabetes mellitus: The primary cause of T2DM is decreased sensitivity of beta cell functioning to the levels of glucose, but recent studies have proven the crucial role Sirt6 in glucose stimulated insulin secretion (GSIS), enhancing the release of insulin (Mahler and Adler, 1999; Song M. Y. et al., 2016; Xiwen et al., 2016) (Figure 3: Schematic representation of molecular mechanism of Sirt6 in various diseases).