Congestive heart failure and coronary artery diseases are the two most common types of cardiac complications associated with Sirt6 activity (Bindu et al., 2016; D’Onofrio et al., 2017; Li et al., 2017; Guo et al., 2019; Yepuri and Ramasamy, 2019). The gene discussed is SIRT6; the disease is coronary artery disorder.