Paeonol (2-hydroxy-4-methoxyacetophenone) has been used as an anti-inflammatory agent (Lou et al., 2017; Zhang L. et al., 2019; Zong et al., 2018; Al-Taher et al., 2020), and also has inhibitory effects on a wide range of cancers including pancreatic, ovarian (Saahene et al., 2018; Gao et al., 2019; Cheng et al., 2020),etc. Recent studies revealed that paeonol could enhance the efficacy of chemotherapeutics, reduce cyclooxygenase-2 (COX-2) and regulate EMT by increasing Human Runt-Related Transcription Factor 3 expression in different types of tumors (Cai et al., 2014; Whittle et al., 2015). Here, PTGS2 is linked to cancer.