Although the role that Nrf2 plays in atherosclerosis is still disputable (Mimura and Itoh, 2015; Freigang et al., 2011; Ruotsalainen et al., 2013), some Nrf2 activators have been shown to exhibit marked activity in combatting atherosclerosis (Zhu et al., 2019; Aboonabi and Singh, 2015; Xie et al., 2016; Lazaro et al., 2018). Here, NFE2L2 is linked to atherosclerosis.