Proteomic analyses are needed to establish that INPs bind to Col I in vivo and to identify other possible INP binding sites in addition to Col I. Collagen I was predominantly found in tumors (Fig. 7 and Supplementary Fig. 6A) and does not appear to be expressed in normal brain (Supplementary Figs. 6B) therefore providing an explanation for the largely tumor-specific INP localization/binding we have shown, b. The gene discussed is NPTX1; the disease is neoplasm.