Nonetheless, we obtained a more comprehensive picture of gastric cancer lymph node metastasis at single-celled resolution, giving a new perspective on the biomarkers (ERBB2, CLDN11 and CDK12) involved in metastasis, pathways involved and driver genes (FOS and JUN) during the metastasis process, providing a basis for the treatment of GC. The gene discussed is FOS; the disease is gastric cancer.