Nonetheless, we obtained a more comprehensive picture of gastric cancer lymph node metastasis at single-celled resolution, giving a new perspective on the biomarkers (ERBB2, CLDN11 and CDK12) involved in metastasis, pathways involved and driver genes (FOS and JUN) during the metastasis process, providing a basis for the treatment of GC. Here, CDK12 is linked to gastric cancer.