In addition, this report suggested the possibility of an association of RhoA in the Nrf2/Keap1 pathway with the motility of lung cancer cells, as significant morphological and cytoskeletal changes were noticed due to the manipulation of Keap1 and suppression of RhoA activity by Keap1 overexpression in Cl1 lung cancer cells15. This evidence concerns the gene NFE2L2 and lung cancer.