FOXO3 and posterior cortical atrophy: A previous study indicated that exposure of LNCaP and C4-2B PCa cells to 50 μM BR-DIM decreased the phosphorylation of GSK3β, and then inhibited nucleus translocation of β-catenin; in addition, it caused FOXO3a to bind to the p27kip1 promoter rather than the AR promoter51.