However, in PCa, the increased level of β-catenin leads to the formation of β-catenin–AR complexes, and the formation of β-catenin–TCF complexes is preferred under the condition of absence of androgen, which express target genes, including AR, c-myc, MMP7, and VEGF19,28. The gene discussed is HNF4A; the disease is posterior cortical atrophy.