When concentrations of inflammatory biomarkers were analysed according to periodontal status, patients with periodontitis presented statistically significant higher levels of IL-6 and CGRP than those without periodontitis (17.0 ± 8.5 vs. 10.0 ± 6.5 ng/mL, P = 0.002 and 19.5 ± 6.9 vs. 15.2 ± 7.8 pg/mL, P = 0.035; respectively) but differences for hs-CRP did not reach statistical significance between groups (3.9 ± 7.0 vs. 2.8 ± 4.8 mg/L, p = 0.465). Here, IL6 is linked to periodontitis.