Another anti-tumor mechanism of metformin is that it can inhibit the expression of MALAT1 and induce the expression of miR-142-3P, destroying the MALAT1/miR-142-3p cavernous body in the nucleus of cancer cells, resulting in the release of miR-142-3p into the cytoplasm, Combined with HMGA2 3′UTR, finally inhibited the invasion and migration of cancer cells34. This evidence concerns the gene HMGA2 and neoplasm.