After overlapping the GSE46517 and TCGA, we identified that KRT1, KRT2, KRT5, KRT6A, KRT6B, KRT6C, KRT8, KRT10, KRT14, KRT15, KRT16 and KRT17 were the most significantly differential expressed keratin family members between primary and metastatic melanoma,displayed in Supplementary Fig. 1 and Supplementary Fig. 2 in detail. The gene discussed is KRT6B; the disease is metastatic melanoma.