Both measures with high ranks indicated 5 SNPs (SALL1 rs10521222; HLA-DQA1 rs9271608; DUSP1 rs17658229; APOC1 rs4420638; and TRAIP rs2352975) and 3 lifestyles (duration of OC and E + P use and BMI) as the most influential variables for breast cancer. The gene discussed is APOC1; the disease is breast cancer.