Cancer and proliferation-related genes such as Wnt7b, S100a14, and Erbb2, were downregulated by thermal ablation in directly-treated tumors (A-T) 1 week after ablation, and to a lesser extent, 24 h after mechanical HIFU (M-T) compared to control (NTC) (Fig. 2A). Here, ERBB2 is linked to cancer.