The univariate analysis identified the following significant factors: the positive expression of Siglec-15 on peritumoral macrophages (HR = 0.404, 95%CI: 0.175–0.933, p = 0.0339), the positive expression of PD-L1 on tumor cells (HR = 0.373, 95%CI: 0.149–0.931, p = 0.0347) and performance of high-dose methotrexate-based chemotherapy (HR = 0.417, 95%CI: 0.183–0.950, p = 0.0373). This evidence concerns the gene CD274 and neoplasm.