Complementary, DCA is capable of inducing COX2 expression through an interaction with PPARα and CREB (Cyclic AMP-Responsive Element-Binding Protein 1) that form a protein-DNA complex together with COX-2 promoter, and, in turn, activate its transcription in human colorectal cancer cell lines39,40. The gene discussed is CREB1; the disease is colorectal cancer.