Although these detected proteins (adenoviral late-gene transcription products) showed no clear differences, levels of E1A protein (an early-gene transcription product involved in viral replication) and IVa2 protein (known to be among the late-gene transcription products L422K, L433K, and IVa2 involved in viral DNA packaging30–33) increased following Ad-3484-shDaxx infection in the various cells (Fig. 2A). Here, DHTKD1 is linked to infection.