Among these TLRs, TLR2 in association with TLR1or TLR6 is essential for sensing bacterial lipoproteins andlipopeptides16,17.The leucine-rich repeats (LRRs) of TLRs are responsible for pattern recognition frombacterial infection and a Toll/IL-1 receptor (TIR) domain is responsible for signaltransduction that inducing the inflammatory responses13.TLR2/1-Pam3CSK4 complex structurerevealed that TLR2 associated with two fatty esters and TLR1 connected with theamide-bound lipid chain18. Here, TLR2 is linked to infection.