Therefore, in the present study, we used CD206 diphtheria toxin receptor (DTR) mice, which enable to deplete CD206+ MΦs, one of a specific marker of M2 MΦ, with diphtheria toxin (DT) injection31,32 to examine the role of CD206+ MΦ in progression of endometriosis. This evidence concerns the gene MRC1 and endometriosis.