Because HBc may be involved in different steps of the HBV life cycle, from the first steps of infection to viral RNA transcription, encapsidation, and reverse transcription, we studied the impact of PTPN3 on HBV replication by following multiple virological parameters after HepG2 NTCP-PTPN3 and HepG2 NTCP infection. Here, PTPN3 is linked to infection.