SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: For example variations in SCN1A, one of the most commonly studied epilepsy genes, can result in a range of epilepsy syndromes55, from generalized epilepsy with febrile seizures plus (GEFS +) to Dravet syndrome (DS), which is associated with intellectual disability and autism56.