CASP9 and Sepsis: For discriminating sepsis, caspase-9 achieved the best receiver operating characteristic curve (AUROC) of 0.95 (95% CI 0.87–0.99, p < 0.001), along with survivin-ΔEx3 = 0.81 (95% CI 0.57–0.97, p < 0.005), survivin-WT = 0.76 (95% CI 0.57–0.94, p < 0.03), and survivin protein = 0.76 (95% CI 0.58–0.95, p < 0.02) (Fig. 4), with CRP exhibiting the worst AUROC = 0.59 (95% CI 0.37–0.83, p < 0.388) (Appendix Table A1).