In experimental sepsis, LPS resulted in a 1.8-fold increase in myocardial caspase-3 activation and a 6.8-fold increase in apoptotic cardiomyocytes through the Akt/eNOS/NO pathway30, whereas cytosolic caspase activation through interferon-β signaling mediated immune responses and lethality27. The gene discussed is CASP3; the disease is Sepsis.