SH3BP5 and Alzheimer disease: In addition, ELISA analysis indicated that the SH3BP5 levels were significantly reduced in cell-broken lysates that were derived from the temporal lobes of autopsied AD patients than those from the non-AD patients (unpaired t-test, p = 0.0084) (Fig. 4g; Supplementary Fig. 14; Supplementary Tables 6 and 7).