The adiponectin level was found to be markedly reduced in the CSFs of AD cases aged 81–88 years old (AD, 0.30 ± 0.07 nM; non-AD, 1.41 ± 0.16 nM; unpaired t-test,  p < 0.0001) (Fig. 4b, Supplementary Table 3). This evidence concerns the gene ADIPOQ and Alzheimer disease.