Given that transgenic overexpression of the mCLSP-1 (Scarf) gene attenuated memory impairment and synaptic loss in the aged APP/PS1 mice without affecting the soluble and insoluble amyloid β levels8, it is likely that the reduction in amyloid β levels is not the main reason for the CLSPCOL-mediated alleviation of memory impaiment. Here, APP is linked to memory impairment.