Immunohistochemical analysis showed that the levels of intraneuronal SH3BP5 were significantly reduced in neurons of AD cortices, compared with those of amyotrophic lateral sclerosis (ALS) cortices (unpaired t-test, p = 0.0256) (Fig. 4e, f; Supplementary Fig. 12; Supplementary Tables 4 and 5). This evidence concerns the gene SH3BP5 and amyotrophic lateral sclerosis.