We next measured the levels of adiponectin in the CSFs, derived from autopsied AD and non-AD cases (Fig. 4a, b, Supplementary Fig. 9, Supplementary Tables 1 and 2) and in the interstitial fluids (ISFs) in the brains of aged male APP/PS1 mice (16-month-old) (Fig. 4c). Here, APP is linked to Alzheimer disease.