In addition, we used the “Lung Adenocarcinoma (TCGA, Firehose Legacy)” dataset at “http://www.cBioPortal.org”38 and found a correlation between KEAP1 mutation and increased expression of various NRF2 target genes (SRXN1, G6PD, GPX2, GCLC, GCLM, and NQO1), which is in line with increased NRF2 activity due to the missing degradation mechanism. The gene discussed is GCLM; the disease is lung adenocarcinoma.