Moreover, predominant neuronal origin of striatal regions depleted in H3K27ac upon age and in response to the HD mutation was supported by DNA motif analysis, showing enrichment in motifs recognized by DLX/GATA and GCM1/2 (Supplementary Fig. 14b), which are transcription factors essential to the establishment of neuronal fate and striatal identity21–25. The gene discussed is GCM1; the disease is Huntington disease.