Among them, two groups of excitatory neurons, THEMIS-PLA2G7 and FEZF2-SCN7A, express several PSGs involved in DNA damage response (Arcas et al. 2014) and mutated in patients with microcephaly such as BRCA1, NHEJ1, RNF168, and TOP3A. This evidence concerns the gene RNF168 and microcephaly.