For example, the PSG FAM111A (raw dN/dS = 2.99; seven nonsynonymous vs. one synonymous mutation in Homo sapiens compared to the common primate ancestor) and ASXL1 (raw dN/dS = 1.83; 12 nonsynonymous vs. three synonymous mutations in Homo sapiens compared to the common primate ancestor) are associated with macrocephaly and microcephaly, respectively. The gene discussed is FAM111A; the disease is Macrocephaly.