Interestingly, MiTF mutations associated with pigment deficiency syndromes and melanoma have different effects on protein function: mutations associated with WS2A and TADS are located in the bHLH-ZIP domains and prevent MiTF from binding DNA, while mutations found in melanoma cases are mostly located at the amino- or carboxy-termini affecting the transactivation potential of MiTF (Fig. 1c) [37]. Here, MITF is linked to melanoma.