Interestingly, genome-wide and targeted analyses have shown that MiTF controls the expression of a set of genes involved in DNA replication and genomic stability in melanoma [165] and, in particular, acts as a critical regulator of the FANC pathway, which plays a key role in the proliferation and survival of melanoma, maintaining the high proliferative potential of melanoma cells and contributing to their high resistance to therapeutics [12]. The gene discussed is MITF; the disease is melanoma.