PCSK5 and cancer: In addition, studies have suggested that both the paired related homeobox 2 (PRRX2) gene [70, 71] and the tumor necrosis factor receptor superfamily member 17 (TNFRSF17) gene [72, 73] are associated with the development of several cancers, while the proprotein convertase subtilisin/kexin type 5 (PCSK5) gene and the WD repeat domain 78 (WDR78) gene have not been reported to be associated with pathogenesis and progression.