In a prostate cancer model, transcriptomic analysis of the tumor microenvironment revealed an increase in the expression of genes associated with pro-tumorigenic macrophages, such as Arg1 Cd163, Mrc1, Retnla, Lyve1, in aged (20–24 months) compared to young male C57BL/6J mice [117]. The gene discussed is CD163; the disease is Familial prostate cancer.