To evaluate the usefulness of exo-oncomiRNAs as potential prognosis biomarkers of PCa aggressiveness in liquid biopsy, we performed logistic regression and receiver operating characteristic (ROC) curve analysis combining the following variables: exo-oncomiR-221-3p, exo-oncomiR-222-3p, exo-oncomiR-31-5p, total PSA, sTWEAK levels and age; Table 3 lists the different combinations. This evidence concerns the gene KLK3 and posterior cortical atrophy.