If we include the two selected exo-oncomiRNAs (exo-oncomiR-221-3p, exo-oncomiR-222-3p) plus PSA levels in serum, the model can predict PCa severity better than is commonly reported by PSA screening alone; however, the model composed of sTWEAK, exo-oncomiR-221-3p and exo-oncomiR-222-3p—all measured in semen—improves not only the percentage of positively diagnosed patients by 2.25%, but increases the specificity by 8%. The gene discussed is KLK3; the disease is posterior cortical atrophy.