AKT1 and neoplasm: Reduced tumor suppressor miR-142 levels in LSCs and TKI-resistant cells were found to be associated with excessive oncoproteins Mcl-1, cKIT, and SRI, precipitating unimpeded PI3K/AKT, JAK/STAT, and RAS/RAF/MEK/ERK downstream signalling with anti-apoptotic, pro-survival and therapy-resistant effects [94,97,106,107,108,109].