However, contradicting evidence was presented in another in vitro study, which showed that IM enhanced mRNA and protein expression of autophagy-related 4B cysteine peptidase (Atg4B), resulting in TKI-induced autophagy and selective survival in CD34+ CML cells (p ≤ 0.05) [39]. The gene discussed is ATG4B; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.