In line with our work, it has recently been described that T-ALL and leukemia stem cells highly express the oxysterol-binding protein (OSBP)-related protein 4 ORP4L, which acts as an adaptor/scaffold assembling CD3ε, Gαq/11, and PLCβ3 into a complex that activates PLCβ3. The gene discussed is PLCB3; the disease is acute lymphoblastic leukemia.