CD3E and acute lymphoblastic leukemia: In T-ALL cells, but not in normal T cells, the expression of ORP4L, a scaffold protein that allows the assembly of CD3ε, Gαq/11, and PLCβ3 into a complex facilitates the activation of PLCβ3 and the generation of inositol 1,4,5 trisphosphate (IP3), the substrate of InsP3R [26].