Regal et al. [40] described two new ALG11-CDG patients presented with ESe and suppression burst activity on EEG and good response to topiramate (TPM) therapy (previous reports were published by Rind et al. [18] and Thiel et al. [41]), abnormal muscle tone with peripheral spasticity, psychomotor delay, microcephaly. This evidence concerns the gene ALG11 and microcephaly.