Molecular chaperones are a heterogeneous class of proteins unified by their primary function of assisting the cellular proteome to achieve and maintain a conformationally mature and functional state [19,20], HSP90α is a chaperone protein that interacts with client proteins that it is closely related to cell apoptosis, metastasis, invasion and chemotherapy resistance, it protects cells from damage and stimuli, promotes tumor cells growth, make tumor cells tolerate chemotherapy, heat treatment and other traumatic stimuli, and finally leads to treatment failure. The gene discussed is HSP90AA1; the disease is neoplasm.