Another potential mechanism is through interaction of its type IV secretion system protein complex with host cell integrin β1, eventually resulting in NF-κB activation and subsequent recruitment of the endonucleases xeroderma pigmentosum group G-complementing protein (XPG, also known as ERCC5) and xeroderma pigmentosum group F (XPF, also known as ERCC4) to host cell chromatin [165,166]. Here, ERCC5 is linked to xeroderma pigmentosum.