Treatment with MET before or after induction of HCC increased the previously ameliorated oxidative stress parameters; however, the maximum improvement was found in the group of rats treated with MET before and after HCC induction (Gp5) which showed the lowest increase in MDA levels and the lowest decrease in SOD, CAT, and GSH levels, when compared to other groups (Figure 6). This evidence concerns the gene GP5 and hepatocellular carcinoma.