Next, the development of the growth factors, EGFR signaling pathway, and the VEGF/VEGFR signaling were the third, sixth, and seventh top detected pathways in the Saudi CRC samples, respectively, all denoting the importance of VEGF/VEGFR and EGF/EGFR pathways which lead to angiogenesis in CRC [3,6,7]. This evidence concerns the gene EGFR and colorectal carcinoma.