The tyrosine kinases identified from the arrays and sequencing-based transcriptomic studies, considered important targets and predictive biomarkers of CRC, were the most common mutated kinases KRAS, RAS/RAF/MAPK, PIK3CA/AKT, TP53, SMAD4, Src-NOS, PLC/ERK, PDGFR/ERK and APC [3,7,10,13]. Here, PIK3CA is linked to colorectal carcinoma.