The PI3K/AKT pathways ranks the first, with the lowest log p-value (Table 2, Figure 2A,B), followed by the inhibition of Ephrin receptors in colorectal cancer (Supplementary material, Figure S1A), growth factor driven development (Supplementary material, Figure S1B), and the oxidative stress ROS-mediated MAPK activation (Supplementary material, Figure S1C) in the fourth rank. This evidence concerns the gene PIK3CD and colorectal cancer.