Previous immunohistochemistry and tissue microarray studies showed that the following mutations are overrepresented in Saudi CRC patients compared with Caucasian CRC patients: telomerase reverse transcriptase (hTERT) in elders, PIK3CA in all ages (exon 9, 12% higher in Saudis), and Rad3-related protein (ATR) in Saudi females compared to males [14]. This evidence concerns the gene PIK3CA and colorectal carcinoma.