The mesenchymal membrane marker CD44 and the adhesion-related protein CD105 (or endoglin) are important markers of stemness in skin-derived fibroblasts and in melanoma cells [24,25,26]; the malignant melanoma is abundant in CD44 and CD105, including the melanoma-initiating cells [27], which confer aggressivity to the tumor growth. The gene discussed is CD44; the disease is neoplasm.