Several of the immune genes were expressed at a significantly lower level in the resistant than sensitive mammary tumors in the HFD offspring not treated with genistein: Foxp3 (p = 0.012), Tgfb1 (p < 0.001), Ctla4 (p = 0.023) and Il6 (p = 0.018). This evidence concerns the gene CTLA4 and breast cancer.