In addition to MG53′s protective role in cardiac and muscular pathology, MG53-mediated repair machinery protects against injury to non-muscle organs including I/R or contrast-induced acute kidney injury [5,15], stress-induced damage in lungs [6,13,14,67], chronic skin wounds [68], and hepatic I/R injury in liver transplantation and hepatic resections [20]. Here, TRIM72 is linked to acute kidney injury.